Let's try and take S4 to 32. It was a brilliant season, after all.
5x13: Dean: Team Free Will.One ex-blood junkie, one drop out with 6 bucks to his name, and Mr. Comatose over there. Awesome.
5x15: Dean: Awesome. Another Horseman. Must be Thursday.
Here's that one from 5x9
Dean: No, I am not a fan. Okay? Not fans! In fact, I think that the Dean and Sam story sucks! It is not fun, it’s not entertaining, it’s a river of crap that would send most people howling to the nuthouse! So you listen to me. Their pain is not for your amusement! I mean, you think they enjoy being treated like circus freaks?
5x14
Sam: You just punched a Cupid!
Dean: I punched a dick!
S4 watching when I get home, check!
the ways I suffer for you people.
eta: unless ita beats me to it.
5x4
Dean: Amphetamines?
Castiel: It's the perfect antidote to that absinthe.
S4 E1 Castiel: I'm the one who gripped you tight and raised you from Perdition.
S4 E2 Dean: All I know is I was not groped by an angel.
S4 E2 Bobby: Solid iron. Completely coated in salt. One hundred percent ghost-proof.
Sam: You built a panic room?
Bobby: (defensively) I had a weekend off.
S4 Ep3 Mary: I want a family. I wanna be safe. You know the worst thing I can think of, the very worst thing, is for my children to be raised into this like I was.
S4 E5 Dean: Brother! I have been rehymenated. And the dude will not abide!
S4 Ep9 Alastair: Don't you recognize me? Oh, I forgot -- I'm wearing a pediatrician.
S4 Ep9 Ruby: This body is 100% socially conscious. I recycle. Al Gore would be proud.
4x6
Sam: Dude, where are you going? That was our hotel.
Dean: Sam, I'm not going to make a left hand turn into on coming traffic. I'm not suicidal. Did I just say that? That's kind of weird.
also from 4x6
Sam: We've been ignoring the biggest clue we had. You...!
Dean: ... I don't wanna be a clue!