Also DaLDoM, S3, but it's dialog rather than mono--
Dean: Dude, you were making some serious happy noises. Who were you dreaming about?
Sam: What? Nothing. Nobody.
Dean: Come on, you can tell me. Angelina Jolie?
Sam: No.
Dean: Brad Pitt?
Sam: No!
3x5
Dean: I'm going to stop the big bad wolf, which is the weirdest thing I've ever said.
4x03 Dean: On November second 1983, don't get out of bed. No matter what you hear, or what you see. Promise me you won't get out of bed.
4x03 Dean: Hey, I wanted to tell you, you know for what it's worth. Um...it doesn't matter what your Dad thinks, I like that John kid.
3x3
Dean: What the hell is wrong with you!? You don't just go around shooting people like that!
Bela: Relax, it's a shoulder hit, I *can* aim.
3x4 Casey: Do you believe in god, Dean? I'd be surprised if you did.
Dean: I don't know. I'd like to.
2x18
Dean: What's a P.A.?
Sam: I think it's kinda like a slave.
The Kids are All Right, S3
Neighbor: 'The' Dean? Best weekend of my life Dean?
Dean: Heh, Gumby Girl. Does that make me Pokey?
2x16
Dean: You know, just once I'd like to round the corner and see a nice house.
2x14
Dean: Dude you... You like full on had a girl inside you for like a whole week.
Searching through these I was able to scratch an itch that was killing me. In 5x18 Point of No Return, Zachariah rolls his eyes and looks really annoyed at the music playing on the jukebox. Superwiki lists the song playing as Kay Starr's "Man Upstairs". And these lyrics are why Zachariah was pissed. [link]
Whew! Now I don't have to ask that at a convention.