S2 2x13 Dean: There's no higher power, there's no God. I mean, there's just chaos, and violence, and random unpredictable evil that comes out of nowhere and rips you to shreds.
Supernatural 2: Why is it our job to save everybody?
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3x08 Young Dean: First thing you have to know is we have the coolest dad in the world. He's a superhero.
3x8
Dean: You fudging touch me agian I'll fudging kill you!
3x11 Sam and Dean: (In unison): Right, you're a mind reader. Cut it out, Sam... Sam! You think you're funny but you're being really, really childish! - Sam Winchester wears makeup. Sam Winchester cries his way through sex. Sam Winchester keeps a ruler by the bed and every morning when he wakes up..... Okay, enough!
S3, Dream a Little Dream of Me
Dean: You're like a father to me!
Demon Dean: The music? That's Dad's. The car, the jacket? All Dad's.
Dean: I don't want to die. And I don't want to go to hell.
Sam: Then we'll find a way to save you.
Dean: Okay, good.
3x08:Dean: What'd Bobby say?
Sam: Uh, that we're morons.
THIS WILL GET MY VOTE FOREVER AND EVER.
3x7
Sam: Yeah, because I've been following you around my entire life. I mean, I've been looking up to you since I was four, Dean. Studying you, trying to be just like my big brother.So, yeah, I know you. Better than anyone else in the entire world. And this is exactly how you act when you're terrified. And, I mean, I can't blame you. It's just...
Dean: What?
Sam: It's just, I wish you would drop the show and be my brother again, 'cause... just 'cause.
3x6
Bela: You know, when this is over, we should really have some angry sex.
Dean: Don't objectify me.
...
Sam: How do you sleep at night?
Bela: In silk sheets, rolling naked in money.
...
Dean: A Hand of Glory? I think I got one of those at the end of my Thai massage last week.
Also DaLDoM, S3, but it's dialog rather than mono--
Dean: Dude, you were making some serious happy noises. Who were you dreaming about?
Sam: What? Nothing. Nobody.
Dean: Come on, you can tell me. Angelina Jolie?
Sam: No.
Dean: Brad Pitt?
Sam: No!
3x5
Dean: I'm going to stop the big bad wolf, which is the weirdest thing I've ever said.