Timelies all!

There was a torrential downpour as we were driving to the concert last night. Luckily, it stopped in time for the concert, which was fun.

How did the babysitter do, Sheryl?

Also, the study in Israel about the Pfizer vaccine was with a very small study group, which means their results should be taken with a grain of salt. I wouldn't panic yet. ND and I are also House Pfizer.

There was a NYT explainer on why the Israel numbers were probably not accurate.

Current estimate is about 85% effective against any symptomatic expression of Delta variant with Pfizer/Moderna. And less than 1% hospitalized or dying.

Of the current literature I've read on Delta, it's generating a much higher viral load, and building up more quickly. So it's more transmissible even in outdoor settings. This has to do in part with its ability to form synctia (new word for me!) or cell clusters that work as viral factories.

A good rundown of the technical aspects of Delta: [link]

"The Delta variants (there's actually more than one in the same viral family), have about 15 different mutations compared with the original virus. Two of these, L452R and E484Q, are mutations to the spike protein that were first flagged as problematic in other variants because they appear to help the virus escape the antibodies we make to fight it.

It has another mutation away from its binding site that's also getting researchers' attention — P681R.

This mutation appears to enhance the "springiness" of the parts of the virus that dock onto our cells, said Alexander Greninger, MD, PhD, assistant director of the UW Medicine Clinical Virology Laboratory at the University of Washington in Seattle. So it's more likely to be in the right position to infect our cells if we come into contact with it.

Another theory is that P681R may also enhance the virus's ability to fuse cells together into clumps that have several different nuclei. These balls of fused cells are called syncytia.

"So it turns into a big factory for making viruses," said Kamran Kadkhoda, PhD, medical director of immunopathology at the Cleveland Clinic in Ohio."

Yeah I think getting moderna if you had Pfizer or vice versa is not likely to help much. J&J it wouldn’t surprise me though.

I’m trying to just enjoy the summer since I kinda figure more lockdowns are likely—or if not official ones, at least “this is maybe not a great idea”

Laura, the babysitter did fine. Apparently Mr. S was an angel for her.

Aims!!! Big hugs to you and Em!

Apparently Mr. S was an angel for her.

Awesome!

Good Monday to all. Also, send birthday wishes to Kat G! I hope this day is filled with delight.

At some point this year we were talking about the perfect descriptive word for the emotion experienced widely in this Covid world. What was it? I can't remember.

Languishing?