4x2
Dean: If He doesn't exist, fine. Bad crap happens to good people. That's how it is. And no rhyme or reason, just random horrible, evil. I get it. Okay? I can roll with that. But if He is out there, what's wrong with Him? Where the hell is He while all these decent people are getting torn to shreds? How does He live with Himself? You know, why doesn't He help?
S1 1x15 Dean: Oh eat me! No, no, no, wait, wait - you actually might!
3x16
Bobby: Family don't end with blood, boy.
S3 3x01 Dean: All I see is the light at the end of the tunnel.
Sam: That's hellfire, Dean.
S2 Ep1 Dean: Yeah, you can't kill Death.
S2 Ep3 Sam: Look, if you two need time alone, just say so.
Dean: (to the Impala) Don't listen to him, baby. He doesn't understand us.
S2 E4 Dean: What's dead should stay dead.
S2 E9 Sam: Dean, you're my brother, alright? So whatever you're carrying, let me help a little bit.
S2 2x11 Sam: You're bossy.
Dean: What?
Sam: You're bossy... and short.
Dean: Dude, are you drunk?
Sam: Yeah. So? Stupid.
S1, Something Wicked
Sam: Dude! I can't use this badge!
Dean: Why not?
Sam: It says 'bikini inspector' on it!
Phantom Traveler
Sam: Are you humming Metallica?
Dean: Calms me down.
Dean: Dude, stow the touchy-feely, self-help-yoga crap. It's not helping!
Wendigo
Dean: Oh sweetheart, I don't do shorts
Dean: Yeah, you want some white meat, bitch? I'm right here!
Haley: Must you cheapen the moment?
Dean: Yeah!
3x14
Sam: It's a Crocotta.
Dean: What's that? Some kind of sandwich?
3x08:Dean: What'd Bobby say?
Sam: Uh, that we're morons.
3x13
Dean: There's a box of salt in my duffel. Make a circle and get inside.
Ed Zeddmore: Get inside your duffel?
Dean: The salt, you idiots!