Kaylee: Captain seem a little funny to you at breakfast this morning? Wash: Come on, Kaylee. We all know I'm the funny one.

'Heart Of Gold'


Natter 71: Someone is wrong on the Internet  

Off-topic discussion. Wanna talk about corsets, duct tape, or physics? This is the place. Detailed discussion of any current-season TV must be whitefonted.


meara - Nov 13, 2012 9:25:23 am PST #699 of 30001

Actually I have wondered on occasion who funds the drug studies that aren't funded by the manufacturer. The FDA?

The FDA requires the drug companies to do certain studies, but doesn't fund them. Basically the manufacturer goes to the FDA before human testing, and says "Here's the results! We want to test humans!" and the FDA says OK or not. And then after that, between testing healthy people, and testing lots of people, they meet with the FDA a few more times to say "This is the results! This is what we plan to test next" and sometimes the FDA says "OK" and sometimes they say "Actually, we also want you to do some tests with people who are on your drug and on (something elese)" or "also add in some neurological tests to make sure your drug doesn't do what (other drug) does" etc.

Most non-industry drug studies are...incredibly smaller. And are funded by things like the NIH, the National Cancer Institute or suchlike, or associations. But often those are just working WITH drug companies on drugs they might otherwise not be able to study, or in ways they might not otherwise.

I have that book in my queue, but I have to say, having worked on the research side (including a LOT of studies that didn't work!), I think the corrupt and icky parts are less the research, and more the "OK, what are we going to develop? Possible new drug that would cost $40 million to do and might not work? Or could we just do some studies to see if our already-approved depression drug also works for bipolar?" or "Hey, let's make more money by pointing out that if we separate our good compound into two, because it's only one form of it that works, we can charge extra and extend our patent life!" and then the sales side ("Well, we haven't actually done STUDIES on migraine, but I'm just saying a lot of doctors prescribe off-label, hint hint" which some companies have gotten in big trouble for).


Burrell - Nov 13, 2012 9:31:43 am PST #700 of 30001
Why did Darth Vader cross the road? To get to the Dark Side!

My first reaction on seeing those lighthouse photos was "holy SHIT!" And I almost never curse out loud anymore.

Thanks for the info on funding, meara.


Typo Boy - Nov 13, 2012 9:32:04 am PST #701 of 30001
Calli: My people have a saying. A man who trusts can never be betrayed, only mistaken.Avon: Life expectancy among your people must be extremely short.

But the one problem is: the Pharm companies will fund multiple studies with the agreement that the data and the studies can only be released with their permission. So if two studies find no problem and 4 find a problem only the two get released. There are other problems too.


Steph L. - Nov 13, 2012 9:34:28 am PST #702 of 30001
the hardest to learn / was the least complicated

Most non-industry drug studies are...incredibly smaller.

Yeah, and then the results aren't generalizable to the larger population.

Or could we just do some studies to see if our already-approved depression drug also works for bipolar?

Or my favorite, "Hey, this guy was taking a drug for angina and he STARTED TO GROW HAIR! Perhaps we can market the bejesus out of this!"


meara - Nov 13, 2012 9:40:52 am PST #703 of 30001

Or my favorite, "Hey, this guy was taking a drug for angina and he STARTED TO GROW HAIR! Perhaps we can market the bejesus out of this!"

Hahaha! And that's totally part of why my job exists too. I'm supposed to review the medical records of people on a study, and confirm that they're reporting all side effects. So, be that "I get headaches on this drug" or "I grew more hair!" or whatever...good and bad. :)


Jesse - Nov 13, 2012 9:40:57 am PST #704 of 30001
Sometimes I trip on how happy we could be.

In fun news, the Good Stuff tumblr has (at least) 1,061 followers now!

I mean, 1392. I should see if I can find out where they are coming from.


Tom Scola - Nov 13, 2012 9:41:24 am PST #705 of 30001
Mr. Scola’s wardrobe by Botany 500

I have 43 followers.


Jesse - Nov 13, 2012 9:44:16 am PST #706 of 30001
Sometimes I trip on how happy we could be.

I feel like I should UNfollow you, just because (as noted) 42 is such a better number!

(But I won't.)


Tom Scola - Nov 13, 2012 9:45:11 am PST #707 of 30001
Mr. Scola’s wardrobe by Botany 500

I bet the followers are via fuckyeahfeminists.com.


Anne W. - Nov 13, 2012 9:46:45 am PST #708 of 30001
The lost sheep grow teeth, forsake their lambs, and lie with the lions.

I should probably do more to get my art tumblr out there, or at least figure out how to tag things to drive traffic to it.