Simon ,'Objects In Space'
Off-topic discussion. Wanna talk about corsets, nail polish, duct tape, or physics? This is the place. Detailed discussion of any current-season TV must be whitefonted.
That seems to work out to Ambien:1, trazadone:0, right?
In my scorecard, yes. But, you know, I only know me, not medicine.
I should also note--I went 41 years without using caffeine to wake me up, EVER. I resent that a sleep specialist is telling me to add another crutch, when I just want to be more normal.
eta: those shoes, with the fiery-coloured crystals, are sexy. Not that I could ever wear them, but still.
Down with the kyriarchy!
I can't stand the bitterness of coffee (or most teas) and don't like sodas either. So the only caffeine I get is courtesy of pills -- about half of one is a coffee cup's worth, so I dole it out in the morning in small increments. Keeps the kick, when I really need it like for a late night drive, that much stronger.
Here's an article - I'm trying to find a link to the original study:
[eta: And here's a link to the study as published in Nature, but it looks like you need an academic login to view more than the abstract:
Caffeine, a widely consumed adenosine A1 and A2A receptor antagonist, is valued as a psychostimulant, but it is also anxiogenic. An association between a variant within the ADORA2A gene (rs5751876) and caffeine-induced anxiety has been reported for individuals who habitually consume little caffeine. This study investigated whether this single nucleotide polymorphism (SNP) might also affect habitual caffeine intake, and whether habitual intake might moderate the anxiogenic effect of caffeine. Participants were 162 non-/low (NL) and 217 medium/high (MH) caffeine consumers. In a randomized, double-blind, parallel groups design they rated anxiety, alertness, and headache before and after 100 mg caffeine and again after another 150 mg caffeine given 90 min later, or after placebo on both occasions. Caffeine intake was prohibited for 16 h before the first dose of caffeine/placebo. Results showed greater susceptibility to caffeine-induced anxiety, but not lower habitual caffeine intake (indeed coffee intake was higher), in the rs5751876 TT genotype group, and a reduced anxiety response in MH vs NL participants irrespective of genotype. Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache. Placebo administration in MH participants decreased alertness and increased headache. Caffeine did not increase alertness in NL participants. With frequent consumption, substantial tolerance develops to the anxiogenic effect of caffeine, even in genetically susceptible individuals, but no net benefit for alertness is gained, as caffeine abstinence reduces alertness and consumption merely returns it to baseline.
And the press release from the research team, which is basically what Reuters published:
My getting stabbed by a fish story is not as dramatic as that.
I'm not sure about those shoes. I like the shiny bauble effect, but I don't like the transparent uppers. They somehow look like they would cut into my toes.
I get nibbled by fish pretty regularly (there's a spot on my back that is apparently quite tasty--they flock), but thankfully never stabbed.
LOLBAT! [link]
flea - insent