Rejection is the writer's lot.
I have this argument with myself over the book I'm working on. Should I try to follow advice on how to make a book more publishable or not. In some ways it feels like a fool's errand since the odds of getting published are pretty damn low, on the other hand, the odds are already low so why make them even lower.
Fortunately, the majority of the advice is stuff that simply makes for better writing. While I haven't changed the story in a substantial way, I have modified things to make it more appealing for agents (according to what I've read, often by agents) and found I really liked how it ended up and wouldn't want to change it back. Turns out agents know what they are talking about.
Wordcount is turning out to be a bitch though, while the exercise of trying to pare out all the unnecessary words is a very good one, I worry I'm not putting in enough to give flavor to the world and some of the characters. It's tough with Fantasy books because so many good ones shatter the maximum recommended wordcount or don't really complete a story.
Oops, rambled. I'm not even sure what my point was anymore.