“Religion is but myth and superstition that hardens hearts and enslaves minds.”
I've seen that one on the buses here, and I always have the dual reaction of, "Oh, fuck you, you fucking fucks, you have no idea why I believe what I do and what I do with that belief" and "Oh, fuck you, Jacqueline, suck it up and deal. The folks who put that up are on the receiving end of some pretty awful stuff 99% of the time, it won't kill you to feel what they feel for the three seconds it takes the bus to pass."
Though those signs are [she said waggishly] preaching to the choir in this city. Or at least among my peer cohort, as actual actively practicing religious people are kinda rare in the white middle class college-educated artists/actors/writers/reenactors communities in the Bay Area. I've gradually, gradually come to realize that I'm not the only one, but it took us years to find each other out because we're all kind of secretive and sheepish and preemptively defensive about it and try not to out ourselves unless we have to. Which, really, is awesomely educational in helping us to get how atheists in most of the rest of the country feel.
Still, those are my second-least-favorite bus ads (the first least favorite is some other ad, for something else entirely, that I can't even remember; I only know it's either aggressively moronic or aggressively sexist and it rages me out so much every time I see it that I have completely blanked the campaign from my mind to prevent myself from stroking out every time I happen to think of it).