88 E. Broadway
This is the Chinatown bus stop, I assume? You'll be closest to the East Broadway stop on the F line, which, coincidentally, is also the line closest to me!
To get to your hotel, take the F train north to 42nd St/6th Ave or to 47-50th St (Rockefeller Center)/6th Ave and walk over to Broadway. You could also change to the A/C/E line at West 4th St, which will let you off a bit closer (42nd/8th).
What day were you thinking of brunching? Sunday is when most places are open, but I know of a few that serve Saturday brunch too. There are a zillion places to eat close to me, or I can research Manhattan brunch options if you'd rather not come out to Brooklyn.