They're letting Jared talk a lot about spoilers:

Star Jared Padalecki says that Sam's experiences in Hell are soon going to boil over, and he will go "bat-ass crazy" and need to be put into an asylum. He also previews another part of Sam's big breakdown:

There's an episode that we're talking about right now where Sam isn't sleeping. The longest anybody's ever gone without sleep is like nine days, and they died, because your organs shut down. I wanted to make sure that we don't have an episode where Sam hasn't slept in a week, and he's losing his mind, and then he suddenly gets it together and helps save the day. I want him to be human, and I want him to be effed up. What's made these characters likable is that they are human.

He also reveals that Sam will be institutionalized in the episode that Misha Collins first returns as Castiel, which will shift the focus to Dean:

Sam never took offense to the fact that Cas had a beef with him. Sam's always been pragmatic and practical. He's like, 'Okay, I guess if I was talking to somebody who messed the whole world up, I'd be hesitant too.' I think with Dean, it's really hard for him to deal with Castiel's betrayal. We've seen Sam wrestle with visions of Lucifer, and now it's Dean's turn to have that kind of a story. We'll see Dean struggle to wrap his head around the Castiel issue. He's like, 'How do we forgive this guy? How do we trust him? That's how we got hurt; that's how we got burned.' Dean's once bitten, twice shy. We'll see him wrestle with some of his own demons.

I'm so down with all of that.

Oh, I know some irrational Wincesters are going to be pissed if Sam goes off the rails while Dean is focussing on Cas and his issues.

Prolly. While I will be enjoying (I imagine) their stories, and looking forward to their eventual reunion! Sometimes it is easy being me.

The longest anybody's ever gone without sleep is like nine days, and they died, because your organs shut down.

Um, no Jared. Maureen Weston went almost 19 days without sleep with no lasting ill effects (she did hallucinate during, though), and Toimi Soini and Randy Gardner each did 11 days with no harm.

The record holder from the 50s, Peter Tripp, did experience a permanent negative personality change after his 8 1/2 days, but that may have been due to the stimulants he used to stay awake rather than the deprivation itself, or entirely coincidental. And he lived long enough to get married and divorced four times afterward.

Tweet him and correct him. It's the only reasonable recourse.

That's two good things -- I really wanted them to revisit Sam's mental state, and for Cas to come back one way or another. So yay!

I can't believe I'm here. I feel like I should go to confession.

Done!

I'm a dirty dirty whore. Who shouldn't really have read what she read, but now that she has, figures she's a dirty slutty whore for the rest of the season.

I may repent. But I may not.